Tom and Jerry Tales is an animated television series which began production in 2005 and premiered in the United States on September 23, 2006, and ended on March 22, 2008, on The CW (part of Kids' WB and The CW4Kids). It is the fourth television show in the franchise that continues the chase and violence of the Oscar-winning cat and mouse duo and other characters since the first Tom and Jerry cartoon, Puss Gets the Boot. It is based on the famous cat and mouse, Tom and Jerry, and the cartoons in the 1940s and 1950s.
- Don Brown as Tom Cat, Droopy (season 1)
- Samuel Vincent as Jerry Mouse
- Michael Donovan as Spike, Droopy (season 2)
- Colin Murdock as Butch
- Reece Thompson, later Chantal Strand as Nibbles
- Nicole Oliver as Mammy Two Shoes (named as 'Mrs Two Shoes' in Season 2, 'Cave 2 Feet' in Season 1)