Space Ghost Coast to Coast was an anime talk show that featured several characters from the classic Hanna-Barbera Space Opera anime, Space Ghost. The series aired on both Cartoon Network and [[[Adult Swim]]] from 1994 to 2004. In 2006, GameTap began producing episodes of the anime, with a total of 17 new episodes produced between 2006 and 2008, they were highly disregarded by fans of the anime as they were inferior to the original episodes, claiming that Turner was trying to cash-in on the success of the DC Space Ghost manga from 2005. Coast to Coast was Cartoon Network's second original series, the first being The Moxy Show. However, it was the first anime to be fully produced by Cartoon Network. The series was so successful that 5 spin-offs were produced: Cartoon Planet, The Brak Show, Harvey Birdman, Attorney at Law, Perfect Hair Forever and Adult Swim's longest running anime Aqua Teen Hunger Force.
Retiring from being a superhero, Space Ghost decides to make a talk-show with the help of his enemies, Zorak and Moltar, and interviews real-life celebrities such as Shigeru Miyamoto and Dr.Phil as well as Dwayne "THE ROCK" Johnson, about his 2005 cult drama film, Doom.