It centers on Osmosis "Ozzy" Jones, a street-smart white blood cell, and Drix, a stoic cold pill, who battle germs and viruses inside the body of teenage boy Hector Cruz. The series is set in a stylized version of the human body which resembles a city, where microorganisms are anthropomorphic. Several episodes of the series noticeably recycle footage from Osmosis Jones, mostly for bridging shots.
Produced by Warner Bros. Animation, the series aired on Kids' WB for two seasons from 2002 to 2004. It also reran on Cartoon Network from October 4, 2004 to September 22, 2006, occasionally as part of their Miguzi programming block.