The film was met with mixed reviews, and earned $14 million against a budget of $70 million. Despite the lack of accolades, it sold well in home media. It also served as the pilot to the Kids' WB television series Ozzy & Drix (2002–04), where Ozzy and Drix get transferred by a mosquito to the body of a teenage boy named Hector Cruz and continue their battle against germs and viruses from there.
Osmosis Jones made its Cartoon Network premiere on December 19, 2003, as part of their Friday night programming block Fridays. It aired on the network several more times until summer 2006, but has not been seen since except once in 2011.
- Chris Rock as Osmosis Jones
- David Hyde Pierce as Drixenol Koldriliff
- Laurence Fishburne as Thrax
- William Shatner as Mayor Phlegmmi
- Brandy Norwood as Leah Estrogen
- Ron Howard as Mayor Tom Colonic
- Richard Steven Horvitz as Red blood cell who talked about free screening
- Bill Murray as Frank Detorre
- as Shane Detorre
- Molly Shannon as Ms. Boyd
- Chris Elliott as Bob