The series follows a group of four teenage detectives, the Clue Club – Larry, Pepper, D.D., and Dottie – who solved mysteries with the help of two talking dogs, a bloodhound and basset hound named Woofer and Wimper. Clue Club mysteries usually involved investigating bizarre crimes such as animals, trains, airports, a movie director, and statues vanishing into thin air.
Clue Club only had one season's worth of first-run episodes produced, which were shown on Saturday mornings on CBS.
In the fall of 1977, cut-down versions of the half-hour episodes of Clue Club appeared under the new title Woofer & Wimper, Dog Detectives to showcase the show's bloodhound and basset hound which aired as a segment on the CBS Saturday morning package program The Skatebirds from September 10, 1977, to January 21, 1978. When The Skatebirds was canceled in early 1978, Woofer & Wimper, Dog Detectives re-appeared as a segment alongside The Three Robonic Stooges on their half-hour show from January 28 to September 2, 1978, also on CBS.
The full-length versions of Clue Club returned to CBS on Sunday mornings from September 10, 1978, to January 21, 1979, concluding the show's original network run. After the mid-1980s re-airing on USA Cartoon Express, it has since resurfaced on Cartoon Network (as part of the Mysteries, Inc. block) in the 1990s and Boomerang in the 2000s.