After moving to New Orleans with her father, Harold and Chester. Mina has a key from her late aunt Marie, who used it to open a cellar in Orlock Apartments. She frees a vampire bunny named Bunnicula. Mina makes Bunnicula a new member of the family.
- Bunnicula: He is the main protagonist of the series. A Vampire Rabbit.
- Chester: A Siamese cat who's afraid of everything.
- Harold: A brown mutt, who's dimwitted and enjoys Bunnicula's antics. He is a reference to Scooby Doo.
- Mina: A 14 year old girl and owner of Bunnicula, Chester and Harold.