2005

1

 * The CN City bumpers are adapted for Latin America.

7

 * Tara Sands takes over from Nzinga Blake as co-host of Fridays.

15

 * Megas XLR ends with the episode "Rearview Mirror, Mirror (Part Two)".

21

 * Foster's Home for Imaginary Friends premieres its second season with the episode "Partying Is Such Sweet Soiree".

25

 * The Powerpuff Girls ends with the episodes "Nuthin' Special/Neighbor Hood" and "I See a Funny Cartoon in Your Future/Octi Gone", both were originally made for seasons 4/5.
 * Star Wars: Clone Wars ends with the episode “Chapter 25”.

28

 * Adult Swim separates from Cartoon Network in the Nielsen ratings and expands to 6AM.

11

 * The CN City bumpers are adapted for United Kingdom and Ireland.

30

 * The Life and Times of Juniper Lee premieres with the episode "It's Your Party and I'll Whine if I Want To".
 * A new summer block called Lumpus and Slinkman's Cabin Fever premieres, replacing Camp Cartoon.

10

 * Season 3 of The Grim Adventures of Billy and Mandy ends with the episode "Wishbones".

17

 * The Grim Adventures of Billy and Mandy premieres its fourth season with the episode "Dream Mutt/Scythe for Sale".

8

 * Camp Lazlo premieres with the episode "Gone Fishin' (Sort of)/Beans Are from Mars".

22

 * Season 4 of Codename: Kids Next Door ends with the episode "Operation: D.O.D.G.E.B.A.L.L./Operation: F.E.R.A.L.".

22

 * Tickle U premieres.

26

 * Season 1 of The Life and Times of Juniper Lee ends with the episode "Monster Con".

24

 * Cartoon Planet returns to reruns on Adult Swim as the last show of the block.

23

 * Bratz Rock Angelz premieres.

29

 * Cartoon Planet leaves reruns again.

31

 * The Life and Times of Juniper Lee premieres its second season with the Halloween special "It's the Great Pumpkin, Juniper Lee".

1

 * Robotboy premieres as a sneak peek with the episode "Dog-Ra/War and Pieces".

24

 * Turkey Days aired, from November 24 to 27.

4

 * Cartoon Network's Holiday Rush aired, from December 4 to 25.

26

 * My Gym Partner's a Monkey premieres with the episode "Inoculation Day/Animal Testing".
 * Sneak Peek Week aired from December 26 to 29.

27

 * Ben 10 premiers as a sneak peek with the episode "And Then There Were 10".