2000

In 2000, Cartoon Network premieres its eleventh original cartoon, Sheep in the Big City. The first original cartoon, The Moxy Show and the sixth original cartoon, I Am Weasel, both end this year.

2

 * I Am Weasel concludes.

6

 * Cartoon Network acquires the broadcasting rights to the Japanese anime series, Gundam Wing, which begins airing edited for content, at 5:30 PM on the Toonami block, with uncut reruns airing at midnight on Toonami's Midnight Run block.

1

 * Cartoon Network’s Boomerang block launches its own spin-off network, although the block will remain until 2004.

25-27
Between August 25th and 27th, the following shorts air as part of The Big Pick:
 * The Grim Adventures of Billy & Mandy: "Meet the Reaper", created by Maxwell Atoms
 * Whatever Happened to Robot Jones?, created by Greg Miller
 * Trevor! in Journey to Sector 5-G, created by Adam Shaheen and Jeff Rockburn
 * Nikki, created by Debby Solomon
 * Foe Paws, created by Chris Savino
 * Prickles the Cactus, created by Denis Morella
 * Lucky Lydia in Club Lydia, created by Arthur Filloy and Bob Camp
 * Longhair and Doubledome: Good Wheel Hunting, created by Gavrilo Gnatovich
 * Lost Cat, created by David Feiss
 * Uncle Gus: For the Love of Monkeys, created by Lincoln Pierce

21

 * Two new shows, The Brak Show and Sealab 2021, premiere, unannounced, early in the morning. This is part of the lead-up to a new adult block that will be premiering in 2001.

26-29

 * Cartoon Theatre: Holiday Week airs.

30

 * Two more new shows, Harvey Birdman, Attorney at Law and Aqua Teen Hunger Force, premiere without any prior advertising.