Osmosis Jones

Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film with animated scenes directed by Tom Sito and Piet Kroon and live-action scenes directed by the Farrelly Brothers. The film centers on Frank Detorre, a slovenly zookeeper; the live-action scenes are set outside Frank's body, while the animated scenes are set inside his body, which is portrayed as a city inhabited by anthropomorphic microorganisms. Street-smart white blood cell cop Osmosis "Ozzy" Jones and stoic cold pill Drix must prevent deadly virus Thrax from killing Frank within forty-eight hours.

The film was met with mixed reviews, and earned $14 million against a budget of $70 million. Despite the lack of accolades, it sold well in home media. It also served as the pilot to the Kids' WB television series Ozzy & Drix (2002–04), where Ozzy and Drix get transferred by a mosquito to the body of a teenage boy named Hector Cruz and continue their battle against germs and viruses from there.

Osmosis Jones made its Cartoon Network premiere on December 19, 2003, as part of their Friday night programming block Fridays. It aired on the network several more times until summer 2006, but has not been seen since except once in 2011.

Plot
Frank DeTorre is an unkempt and slovenly zookeeper at the Sucat Memorial Zoo in Rhode Island. Frank is also a widower. Depressed by the loss of his wife years earlier, he copes by eating unhealthy and not exercising, to the annoyance of his young daughter Shane. Inside his body, white blood cell Osmosis "Ozzy" Jones is a rebellious officer of the Frank Police Department, the city's center for immune responses against bodily threats. Ozzy was demoted to patrol duty in the mouth after an incident where he induced Frank to vomit against orders, resulting in Frank being fired from his previous job at a pea soup factory and banned from visiting Shane's school due to a restraining order filed by her P.E. and science teacher, Mrs. Boyd.

Two years later, facing a serious challenge to his reelection prospects, Mayor Phlegmming doubles down on his junk food policies, ignoring their effect on Frank's health. This causes Frank to eat a boiled egg covered in filth, allowing Thrax, a deadly virus, to enter the throat. Unwilling to admit responsibility, Phlegmming instructs Frank to take a cold pill through brain signals. The pill, Drixenol "Drix" Koldreliff, proceeds to disinfect the throat, covering up any evidence of Thrax's arrival. To his displeasure, Ozzy is subsequently assigned to assist Drix in his investigation. Meanwhile, Thrax assumes leadership of a gang of sweat germs and launches an attack on the mucus dam in Frank's nose, nearly killing Drix before Ozzy rescues him. The two pay a visit to one of Ozzy's informants, who reveals Thrax's plan to pose as a mere cold virus as a cover for killing Frank with a high fever in order to become the next big virus in the medical records. Based on his information, Ozzy goes undercover at a nightclub intending to infiltrate Thrax's gang, only to be discovered and forced to call in Drix, who manages to destroy the club with a grenade. The explosion pops a zit on Frank's forehead during a meeting with Mrs. Boyd, ruining any chance for him to apologize. In response, Phlegmming closes the investigation, has Ozzy fired from the force, and orders Drix to leave the city.

Having survived the assault, Thrax eliminates his remaining henchmen and launches a lone assault on the hypothalamus gland (the portion of the brain that controls body temperature), where he steals a DNA bead. He then abducts the Mayor's secretary, Leah Estrogen, and flees to the mouth to escape. His actions disable the body's ability to regulate temperature, causing the city to break out in flames and panic. As Frank is taken to the hospital in a fever coma, Ozzy and Drix reconcile and proceed to rescue Leah. They succeed, but Thrax is able to exit the mouth using pollen as a distraction. Ozzy pursues him to the surface of Shane's eye, and as they fight they both land on one of Shane's false eyelashes. As Thrax has Jones pinned down after Jones recovers the DNA bead, he gloats over how he will break his record by killing Shane as his next victim, but gets stuck in the false eyelash; Jones escapes at the last minute before the eyelash slides off and lands in a vessel of rubbing alcohol, where Thrax melts.

As Frank's temperature goes over 108 degrees, his heart begins to shut down and flatline. Riding one of Shane's tears, Ozzy reenters his body with the bead in hand and replaces the missing chromosome, reviving Frank from his momentary state of death. Having narrowly cheated death, Frank commits himself to living a healthier lifestyle, and Ozzy and Drix are declared heroes, with Ozzy having been reinstated to the force with Drix as his new partner, at which point Ozzy also begins a relationship with Leah. Frank and Shane go hiking, as he attempts to live a healthier life. Phlegmming, meanwhile, is impeached from office due to his actions having nearly killed Frank and the City of Frank with him, resulting in his opponent Tom Colonic winning the election by a landslide and himself reduced to a custodian in the bowels, where he ejects himself accidentally by triggering Frank's flatulence.

Cast

 * Chris Rock as Osmosis Jones
 * David Hyde Pierce as Drixenol Koldriliff
 * Laurence Fishburne as Thrax
 * William Shatner as Mayor Phlegmmi
 * Brandy Norwood as Leah Estrogen
 * Ron Howard as Mayor Tom Colonic
 * Scabies
 * Bruiser
 * Richard Steven Horvitz as Red blood cell who talked about free screening
 * Bill Murray as Frank Detorre
 * as Shane Detorre
 * Molly Shannon as Ms. Boyd
 * Chris Elliott as Bob